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Of the 1,267 adult participants with obesity who took part in the trial, the mean weight loss percentages were as follows by 56 weeks: For those who took a placebo: 2.1% For those who took a 3.75/23 mg dose: 6.7% For those who took a 15/92 mg dose: 14.4% Participants in both clinical trials involved diet and exercise as part of their treatment plan