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Circulation 105(1):112117 Morikawa S et al (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

Safety across the full program was consistently favorable: adverse events, primarily mild headache and gastrointestinal symptoms, occurred at rates comparable to placebo, with no treatment-related discontinuations, no IGF-1 elevation, and no impact on glucose metabolism

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