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Cytokine Measurement Levels of IL-2, IL-6, IL-12, IL-17, IL-10, IFN-, TGF-1, and TNF- were measured in the lung tissue homogenates from untreated, 40 mM L-GSH, RIF, and RIF +40 mM L-GSH treated mice using enzyme-linked immunosorbent assay (ELISA) kits: IL-12 p70 Mouse Uncoated ELISA Kit (Cat # 887,12188), IL-6 Mouse Uncoated ELISA Kit (Cat # 887,06488), IL-2 Mouse Uncoated ELISA Kit (Cat #887,02488), IL-17A (homodimer) Mouse Uncoated ELISA Kit (Cat # 887,37186), IL-10 Mouse Uncoated ELISA Kit (Cat

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safety and tolerability Key Results Weight Reduction Mean percentage change in weight at week 48: 1 mg: 8.7% 4 mg: 17.1% 8 mg: 22.8% 12 mg: 24.2% Placebo: 2.1% 100% of participants on 8 mg and 12 mg achieved 5% reduction