The Institute for Health Metrics and Evaluation (IHME) estimates that high body mass index accounts for more than 160 million disability-adjusted life years globally, while diabetes prevalence continues to rise steadily, reinforcing demand for effective therapies like GLP-1 receptor agonists
Treatment options for recurrent or metastatic MTC include surgical resection, external beam radiation therapy (EBRT), and directed local therapies or systemic therapies [1,4]
In early studies, selective knockout of the GPX4 gene in hippocampal neurons promotes neurodegeneration and cell death in a non-apoptotic manner, which provide preliminary evidence for GPX4 as a particular regulator of ferroptosis (Seiler et al., 2008)
Drugs 11 , 11071115 (2010)
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