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In the 64-week OASIS 4 trial (307 adults), mean weight loss was 13.6% under the treatment-policy analysis and 16.6% among participants who stayed on treatment, versus about 2% on placebo

Side effects look benign at researched doses

Oral formulations of both medications provide non-injection alternatives at $249 monthly for semaglutide and $279 for tirzepatide, accommodating patient preferences around needle anxiety or convenience

From the clinical perspective, GLP-1R gene polymorphism is associated with AUD, and exenatide moderately reduces alcohol drinking in overweight AUD patients

Similarly, in a meta-analysis by Jirapinyo et al

Stay Hydrated: GLP-1s can reduce thirst, increasing the risk of dehydration