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Strongest human evidence (topical) The Leyden 2002 photoaging trial in 71 women applied a GHK-Cu facial cream for 12 weeks and reported measurable improvements in skin density, thickness, fine lines, and laxity

One is by up-regulating a signaling protein called VEGF (vascular endothelial growth factor), which encourages the growth of new capillaries

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Their tirzepatide/niacinamide formulation and tirzepatide ODT are designed to meet this requirement