glp 1 for crohn's agonist disease ADJUNCTIVE GLP-1 RECEPTOR AGONISTS IN DISEASE: REDUCED STEROID DEPENDENCE AND HOSPITALIZATIONS IN A REAL-WORLD MULTI-NETWORK COHORT Alimentary Pharmacology & Therapeutics GLP-1RAs for IBD | Docwire

It was originally discovered by researchers at Tulane Medical School who were looking for a way to stimulate growth hormone production via the growth hormone secretagogue receptor (GHS-R) without simultaneously increasing other hormonesas often observed in exogenous growth hormone (GH) therapy [1]

Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]

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doi: 10.1016/S2215-0366(20)30462-4