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Weight loss is less in rodent models where iNKTs are deficient, even when GLP-1R agonists still induce satiety, implicating GLP-1 in increasing energy expenditure [111]

Four RCTs [17, 18, 32, 35] involving 291 patients provided moderate certainty evidence (Table 2) that L-carnitine supplementation has no difference in changes in weight (MD: 0.20, 95%CI: 0.50 to 0.09)