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For the shotgun metagenomic sequencing, one mouse was randomly selected from each of the three replicate cages per group

The parent protein was identified during investigations of compounds in human gastric juice that conferred protection against ulceration, and the active 15-residue fragment retained the full activity of the larger protein in subsequent characterisation studies

doi: 10.1210/clinem/dgae026

"Thats why these taste shifts are often more pronounced early on, and tend to settle once the patients weight stabilises." Other theories include the presence of GLP-1 receptors in taste buds themselves, which may alter how we process flavour, and the slowing of digestion, which can make foods feel heavier and affect how theyre perceived in the mouth

There are also effects on satiety via actions within the brain