In these clinical trials, 42% of patients lost 5% or more of their body weight, 21% of patients lost 10% or more, and 10% of patients lost 15% or more
A small piece was removed from the core of the tumor and transferred to the media and minced into small pieces and transferred into a 6 cm culture dish and cultured in DMEM with 10% FBS and pen+strep
Overcoming Plateaus: It is common for weight loss to slow down after several months of treatment
This has not yet been shown the same way in humans, so it is best described as a promising mechanism, not a proven effect
Future research should aim to deepen our understanding of drug resistance mechanisms, with a focus on developing precision medicines tailored to specific resistance profiles
Front Immunol 13:856376 Rhinn H, Tatton N, McCaughey S, Kurnellas M, Rosenthal A (2022) Progranulin as a therapeutic target in neurodegenerative diseases