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2026 Jan 7;392:e085304

Abstract Barrett oesophagus (BE), the only known histological precursor of oesophageal adenocarcinoma (EAC), is a condition in which the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive response to gastro-oesophageal reflux

Week 1-4: Initial response (starting dose titration) Physical changes: 4-8 pounds weight loss (mostly water and reduced food volume in system) Appetite dramatically reduced Less frequent hunger signals What photos show: Minor changes

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These drugs increase insulin secretion, suppress appetite, slow stomach emptying, and lower glucagon levels , reducing the risk of glucose spikes after meals