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These fragments stimulate inflamed synovium cells (synoviocytes, macrophages, lymphocytes) to secrete cytokines, chemokines, and lipid mediators, as well as more ROS and MMPs, which can directly degrade the components of the cartilage matrix or dysregulate the metabolism of chondrocytes, leading to an imbalance between cartilage matrix degradation and synthesis

The logic is straightforward: the two drugs work through completely different pathways

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Nutr Cancer 1994

Melanotan 1 is administered subcutaneously, meaning into the fatty tissue just under the skin