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Disulfide cross-linking validates the physiological relevance of the closed conformation, while electron microscopy (EM) and molecular dynamic (MD) simulations suggest a large degree of conformational dynamics of ECD that is necessary for binding GLP-1

Methionine is an essential amino acid that assists in breaking down fat within the liver

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Finally, several small molecules with moderate activity were obtained in the screening, including several derivatives of naphtoquinones, which are also inhibitors of the NF-B pathway (Supplementary Table 4)

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