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Ample genetic evidence proves Mc4r signaling to be a critical component of the body-weight regulation system

28 AT 2 receptors are upregulated in the adult kidney in response to sodium depletion 27 or kidney damage 29 in obese Zucker rats 30 and spontaneously hypertensive rats (SHRs)

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Regulation of PRPP synthesis is effected through complex allosteric regulation of PRPP synthetase

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