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21 But now we are seeing hard evidence that may make covering GLP-1s a more palatable call

Both medications come in multiple dosing options but are always started at the lowest dose and then titrated up as needed

However, more people reported higher rates of side effects while on orforglipron compared to Rybelsus, which caused them to stop taking the pill

Both contain semaglutide, a once-weekly injection

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In the United States, FDA approved four-dose Mounjaro and Zepbound KwikPens on January 20, 2026, while single-dose Mounjaro and Zepbound pens and vials also remain in use