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Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

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10.1016/j.freeradbiomed.2018.03.001 33 Friedmann AngeliJ

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The timing of intervention may also be key