One study (87) provides evidence that pro-GLP-1 prevented apoptosis induced by oxygen-glucose deprivation (OGD) in cultured cortical neurons, and exerted neuroprotective effects through the cAMP/PKA and PI3K/Akt signaling pathways but not the ERK pathway in mice against cerebral ischemia
10.1016/j.ejphar.2018.07.031 12 alarY.zgrH.MaturI.YenilmezE
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA (2008) Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimers disease
Stress, fatigue and 'brain fog' as well as reduced physical stamina are common side effects of Vitamin B12 deficiency
The anti-inflammatory and neuroprotective properties of GLP-1s, along with their metabolic effects, make them ideal candidates for these multifactorial diseases
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