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Biliary Copper Excretion Bile is the major physiologic route for eliminating excess copper

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Wang FK, Song X, Ma SS, et al

The discovery has revealed that natural plant polysaccharides possess the ability to exert antidepressant effects through the regulation of neurotransmitters and their receptors, modulation of the HPA axis, control of inflammatory responses, management of oxidative stress, modulation of neurotrophic factors, regulation of gut microbiota and tryptophan metabolism, as well as other pathways

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Other dopamine receptors could also influence LID progression, as L-DOPA may decrease (Brooks et al., 1992