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Cardiovascular Risk Factors Triglyceride reduction: 28% Systolic blood pressure reduction: 6.8 mmHg Waist circumference reduction: Significant HDL cholesterol: Modest improvement Both compounds reduce blood pressure, improve lipid profiles, and decrease markers of inflammation

doi: 10.1210/jc.2003-031403 208 LovshinJABarnieADeAlmeidaALoganAZinmanBDruckerDJ

I numeri da tenere a mente Riduzione MACE (eventi cardiovascolari maggiori) Semaglutide vs placebo : 26% nel diabete con alto rischio CV (SUSTAIN-6) 20% nellobesit con malattia CV (SELECT) 14% con la formulazione orale (SOUL) Tirzepatide vs dulaglutide : 12,2% vs 13,1% MACE-3 a 4 anni (non inferiorit raggiunta, p=0,003) Mortalit totale Semaglutide : dati positivi in FLOW (20%) e SOUL Tirzepatide : 16% rispetto a dulaglutide (SURPASS-CVOT) Perdita di peso a 72 settimane (dose massima) Semaglutide 2,4 mg : 14,9% (STEP-1, senza diabete) 9,6% (STEP-2, con diabete) Tirzepatide 15 mg : 22,5% (SURMOUNT-1, senza diabete) 15,7% (SURMOUNT-2, con diabete) Steatoepatite (MASH F2-F3, 72 settimane) Semaglutide 2,4 mg (ESSENCE): risoluzione MASH 62,9% vs 34,1% placebo Tirzepatide 10-15 mg (SYNERGY-NASH): risoluzione MASH 51-62% vs 10% placebo Domande frequenti (FAQ) Qual la differenza tra Ozempic, Wegovy, Rybelsus e Mounjaro

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doi: 10.1046/j.1365-2958.2002.03194.x 147 SuhP

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