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For short-term or mild adverse events, dietary modifications are warranted and, for constipation, increased fiber/water intake can be recommended
It lowers their blood sugar and reduces the risk of heart attacks and strokes among those who also have heart disease
Now its true, this was not a randomized controlled trial and thats what makes it real world data
Reported and Theoretical Risks Mild transient headache or nausea reported in some early human studies
mechanistically, the former inhibits PCSK9 translation by binding to the 80S ribosome, while the latter does so through inhibition during the elongation phase (Li et al., 2019)