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[Source: Fierce Pharma ] February 2025 Eli Lilly committed another $5.3 billion toward a manufacturing hub in Indiana to meet explosive demand for Mounjaro and Zepbound

Orforglipron, developed by Eli Lilly, is the first non-peptide oral GLP-1 agonist, achieving up to 1.8% HbA1c reduction and 1012% body-weight loss in Phase 3 trials

Mounjaro (tirzepatide) is typically dosed weekly, not daily

The FDA and other policymakers should take immediate action to ensure the integrity of the FDA's rigorous regulatory review and approval process, the drug supply chain and decades of carefully balanced approaches to fostering innovation and generic competition. Eli Lilly, Novo Nordisks rival in the diabetes and obesity market, also is expected to launch a weight-loss pill, orforglipron, in the first half of this year

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Notably, QMP engineering ensures favorable pH-dependent FcRn binding, also in the absence of the C-terminal leucine residue