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& Nachtigal, P

Evidence-Based Complementary and Alternative Medicine (2011)

Mechanistically, CB-839 elevates the levels of intracellular ROS, enhances the movement of Nrf2 into the nucleus, leading to an increase in uridine phosphorylase 1 (UPP1) mRNA expression

The samples were resolved on an ACQUITY UPLC BEH C18 column (100 2.1 mm i.d., 1.7 m particle) using water and acetonitrile as mobile phases A and B, respectively, at a flow rate of 0.15 ml min 1 and a column temperature of 40 C