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In a 12-week trial of mecasermin rinfabate (IPLEX) in adults with ALS (N=330), symptomatic hypoglycaemia occurred in 6.8% of the active arm versus 2.4% of placebo [16]

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Measurements: The primary outcome was incident ION as a proxy for NAION

In the CY 2026 OPPS/ASC proposed rule, we welcomed comments on whether other common drug discount programs have a similar structure or should otherwise also be separately noted

Use both only with a clearly structured protocol when the research goal spans both collagen/skin support and deeper tissue recovery