A., Hsiao, J
Currently, there seem to be supportive data that GLP-1 RAs can have beneficial outcomes in neurodegenerative diseases such as PD

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While LEADER and ELIXA were similar in terms of their overall design, there were some major differences between the patient populations enrolled in the two studies
Its about finding the minimum effective dose, not the maximum tolerable one
However, clinical studies showed that inhibition of IGF-1R has very limited efficacy due to the development of resistance to IGF-1R blockade in tumor cells