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Munoz-Rojas, A

Spatial learning and memory deficits observed on the morning of proestrus phase in rodent are associated with an increased expression of 4 GABA A Rs on CA1 pyramidal cell dendrites (230)

Plasma half-life (IV, rat): approximately 15.2 minutes [10]

The 2B3-201 product has recently completed a phase I trial in healthy volunteers [146], while the 2B3-101 product has completed a phase I/IIa trial in patients with various forms of brain cancer (ClinicalTrials.gov Identifier: NCT01386580 [147,148]) and is currently being tested in a phase II trial in patients with breast cancer and leptomeningeal metastases (ClinicalTrials.gov Identifier: NCT01818713)