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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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If you take your dose early once, avoid falling into a pattern of early injections every week, as this gradually compresses your dosing schedule and could eventually lead to unintended dose frequency changes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Galvez-Ontiveros Y., Paez S., Monteagudo C., Rivas A

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